APAvadis is developing products for innovative diagnostic and therapeutic approaches.

Such modular systems will be assembled from 3 molecules with the following characteristics:

1. AN ADDRESSER: a short peptide, with binding selectivity for the following targets:
   1. Aminopeptidase A, a human transmembrane molecule over-expressed in angiogenic blood vessels and functionallyinvolved in tumor angiogenesis;
   2. Epithelial/endothelial cells in human liver metastases secondary to colorectal cancers;
2. A CARRIER: a biocompatible nanocarrier for the controlled delivery of the active molecules, one of the following depending on the application:
   1. PEG-liposomes for the veiculation of chemotherapeutic agents;
   2. Filamentous phages or silica core-shell nanoparticles for nanoshuttle veiculation of diagnostic agents.
3. AN ACTIVE MOLECULE, one of the following categories:
   A THERAPEUTIC AGENT:
   1. Prototype chemotherapeutics for system validation;
   2. Disease-specific chemotherapeutics for target applications;
   
   A DIAGNOSTIC AGENT:
   1. New generation fluorophores emitting in the red/infrared spectral region;
   2. Gold and silica nanoparticles for fluorescence enhancement and direct Raman spectroscopy detection.